ASST. PROF. CHARUPONG SAENGBOONMEE

Cancer Biology; Metabolic Disorder; Diabetes Mellitus; Nutrition; Epidemiology

ResearchGate

Timeline

  • 2016 Ph.D. (Medical Biochemistry and Molecular Biology), Khon Kaen University, Thailand
  • 2019 M.D. (First Class Honor), Khon Kaen University, Thailand
  • May – Sept 2019 Medical Physician, Practitioner Level, Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Thailand
  • Oct 2019 – present Lecturer, Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Thailand
  • Jan 2020-Dec 2021 Visiting Scientist, Department of Genetics, Harvard Medical School, and Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard University, USA

Short Course Training and Visiting Programs

  • Organic synthesis, Department of Chemistry, Universite’ Catholique de Louvain, Louvain-la-nueve, Belgium (Prof. Istvan E. Marko’s Lab)
  • RNA sequencing, Human Genome Sequencing Center, Baylor College of Medicine, TX, USA (Nucleic Acid Lab, Prof. MC. Gingras)
  • Medical Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University, OH, USA
  • Family Medicine, National Cheng Kung University, Taichung, Taiwan

Scholarships, Awards and Achievements

  • Junior Science Talent Project (JSTP), National Science and Technology Development Agency, (High School -Ph.D.)
  • Ph.D. -M.D. Program, Faculty of Medicine, Khon Kaen University
  • Young Thai scientist delegate, Lindau Nobel Laureate Meeting 2013 (Chemistry), Germany
  • Outstanding Ph.D. Dissertation (Health Science) Year 2017, Graduate School, Khon Kaen University
  • Prince Mahidol Award Youth Program, Year 2018
Outstanding PhD dissertation award of the Year 2017, Graduate School, KKU
Scholar of Prince Mahidol Award Youth Program of the Year 2018
Delegate of young Thai scientists participated in Lindau Nobel Laureate Meeting 2013 (Chemistry) in Germany

Ad Hoc Reviewer

  • Life Science (IF: 3.462, Elsevier)
  • BMC Cancer (IF: 3.150, Springer-Nature)
  • BMJ Open Diabetes Research and Care (IF: 3.183, BMJ)
  • Journal of Diabetes (IF: 3.280, Wiley)
  • World Journal of Surgical Oncology (IF: 2.234, Springer-Nature)
  • Medical Science Monitor (IF: 1.918, Medical Science International Publishing)
  • Pharmacognosy Magazine (IF: 1.310, Wolters Kluwer)

Research Interest in Brief

My field of interest is the association between metabolic disorder, diabetes mellitus, nutrition and the carcinogenesis and progression of cancer.

Detailed Profile and Featured Work

My research interest is focused on the association between metabolic disorder, diabetes mellitus, nutrition, and the carcinogenesis and progression of cancers. Initiated with some studies in cholangiocarcinoma (bile duct cancer), my interests are now expanding to the other types of cancer, e.g., liver, breast as well as gynecological cancers. Using epidemiology together with a molecular approach, my colleagues and I are working to better understand the associations among these non-communicable diseases. With a collaboration with groups in other universities in Thailand as well as international collaborators at Harvard Medical School and Human Genome Sequencing Center, Baylor College of medicine, USA, my research work is extending to study to overcome drug resistance of cancer cells as well as to use a genetic approach for precision diagnosis and treatment of cancer.

New collaborators and students of all disciplines are welcome to join our research. Highly talented high school students (including but not limited to JSTP, DPST, Scius) who are interested in the research in medical science are also welcome. Please email me if you think we have our interest in common.

Invited speaker for research inspiration for high school student in SCiUS Program – Science Classrooms in University-Affiliated School (วมว)

Selected Publications

1. Detarya M, Thaenkaew S, Seubwai W, Indramanee S, Phoomak C, Saengboonmee C, Wongkham S, Wongkham C. High glucose upregulates FOXM1 expression via EGFR/STAT3 dependent activation to promote progression of cholangiocarcinoma. Life Sci. 2021 Jan 26;119114. doi: 10.1016/j.lfs.2021.119114.

2. Saengboonmee C, Phoomak C, Supabphol S, Covington KR, Hampton O, Wongkham C, Gibbs RA, Umezawa K, Seubwai W, Gingras MC, Wongkham S. NF-κB and STAT3 co-operation enhances high glucose induced aggressiveness of cholangiocarcinoma cells. Life Sci. 2020; 262: 118548. doi: 10.1016/j.lfs.2020.118548.

3. Saengboonmee C, Seubwai W, Lert-Itthiporn W, Sanlung T, Wongkham S. Association of Diabetes Mellitus and Cholangiocarcinoma: Update of Evidence and the Effects of Antidiabetic Medication. Can J Diabetes. 2020 Sep 17;S1499-2671(20)30376-2. doi: 10.1016/j.jcjd.2020.09.008.

4. Saengboonmee C, Sawanyawisuth K, Chamgramol Y, Wongkham S. Prognostic biomarkers for cholangiocarcinoma and their clinical implications. Expert Rev Anticancer Ther. 2018; 18(6): 579-592. doi: 10.1080/14737140.2018.1467760.

5. Phoomak C, Vaeteewoottacharn K, Silsirivanit A, Saengboonmee C, Seubwai W, Sawanyawisuth K, Wongkham C, Wongkham S. High glucose levels boost the aggressiveness of highly metastatic cholangiocarcinoma cells via O-GlcNAcylation. Sci Rep. 2017; 6; 43842. doi: 10.1038/srep43842.

6. Saengboonmee C, Seubwai W, Cha’on U, Sawanyawisuth K, Wongkham S, Wongkham C. Metformin Exerts Antiproliferative and Anti-metastatic Effects Against Cholangiocarcinoma Cells by Targeting STAT3 and NF-ĸB. Anticancer Res. 2017; 37(1): 115-123. doi: 10.21873/anticanres.11296.

7. Saengboonmee C, Seubwai W, Pairojkul C, Wongkham S.  High glucose enhances progression of cholangiocarcinoma cells via STAT3 activation. Sci Rep. 2016; 6: 18995. doi: 10.1038/srep18995.

8. Saengboonmee C, Seubwai W, Wongkham C, Wongkham S., Diabetes mellitus: Possible risk and promoting factors of cholangiocarcinoma: Association of diabetes mellitus and cholangiocarcinoma. Cancer Epidemiol. 2015; 39 (3): 274-8